Geale K et al. However, patients who were receiving bDMARD monotherapy (without methotrexate) and had widespread skin involvement (body surface area: >10%) showed improved drug persistence with ustekinumab, compared with TNFi (HR: 0.61; 95% CI: 0.42–0.90, and HR: 0.41; 95% CI: 0.19–0.89, respectively).11. Persistence was compared using a Cox regression analysis, with PS adjustments for baseline imbalances in demographics and disease-related covariates. In patients with PsA and axial involvement, guselkumab was associated with a reduction in axial symptoms after 24 weeks of treatment. EULAR Cardiovascular involvement in Inflammatory arthritis (CVIIA) Study Group Smolen JS et al. ... Poster View Add to calendar: More ... Baricitinib, Tofacitinib, Upadacitinib, Filgotinib, and Cytokine Signaling in Human Leukocyte Subpopulations: an Updated Ex-Vivo Comparison Nuki 04. The face-to-face annual congress in Frankfurt in June this year has been cancelled due to the unprecedented situation. Concomitant methotrexate use and skin involvement (body surface area: <3%, 3–10%, and >10%) were added to the Cox model to observe their possible influence on the PS-adjusted treatment effect. Treatment with the IL-12/23 inhibitor ustekinumab resulted in comparable MDA, VLDA, and cDAPSA outcomes and favourable persistence profiles, compared with TNFi, in patients with PsA. Last accessed: 25 June 2020. Abstract FRI0362. A study on assessment of STELARA and tumor necrosis factor alpha inhibitor therapies in participants with psoriatic arthritis (PsABIO). Guselkumab treatment resulted in prolonged improvements in joint and skin symptoms, as well as inhibition of radiographic progression, through Week 52.4, A study examining the efficacy and safety of guselkumab in patients with PsA with imaging-confirmed axial involvement consistent with sacroiliitis in the DISCOVER-1 and -2 trials, found that treatment was associated with a reduction of axial symptoms after 24 weeks of treatment. Findings for the PASI 75 and 100 responses were similar to those of PASI 90. Privacy Policy We'll assume you're ok with this, but you can opt-out if you wish. Rigel Pharmaceuticals, Inc. ... (EULAR) 2020 E-Congress taking place June 3-6, 2020. All rights reserved. 03 June 2020 16:30 - 16:45 Add to calendar : Points of difference between EULAR and ACR publications. A personalized account is required to proceed. UmeÃ¥ Universitet, UmeÃ¥, Sweden. This article explores applying the principle of prehabilitation to patients with rheumatoid arthritis prior to starting advanced therapies, including…. Read more Biennial report 2020 Congress poster 2019. The results of the multivariate main analysis showed that patients receiving ustekinumab had significantly lower discontinuation rates, compared with adalimumab (HR: 0.56; 95% CI: 0.49–0.64). Treatment persistence (up to 15 months of follow-up) was defined as time between start of first biologic disease-modifying antirheumatic drug (bDMARD) treatment in PsABIO, stopping or switching to another bDMARD, or withdrawal from treatment. Latest Highlights on Biologic Treatments for Psoriatic Arthritis from EULAR 2020, Efficacy and Persistence of Ustekinumab in Sweden. 2020;79(1):37-8. Ustekinumab and TNF inhibitors in psoriatic arthritis: first follow-up data from a routine care study in 8 European countries (PsABIO). To evaluate changes in microbial composition and the evolution of gastrointestinal tract (GIT) symptoms in systemic sclerosis (SSc). A comparative analysis of guselkumab showed that it ranks consistently equally with other PsA treatments in terms of PsA-related measurements, including improvements in arthritis, soft-tissue damage, physical function, and safety outcomes. https://clinicaltrials.gov/ct2/show/NCT03158285. 2. Janssen Research & Development, LLC. The aim of the European Congress of Rheumatology is to provide a forum of the highest standard for scientific (both clinical and basic), educational and social exchange between professionals involved in rheumatology, liaising with patient organizations, in order to achieve progress in the clinical care of people with rheumatic diseases. Janssen. SEATTLE--(BUSINESS WIRE)--May 29, 2020-- Alpine Immune Sciences, Inc. (NASDAQ: ALPN), a leading clinical-stage immunotherapy company focused on developing innovative treatments for cancer and autoimmune/inflammatory diseases, today announced that the company will present two posters at the EULAR 2020 E-Congress, taking place virtually June 3-6, 2020. Further evidence for ustekinumab’s favourable treatment persistence profile comes from a population-based study in Sweden comparing time to discontinuation of a TNFi (adalimumab), an IL-17 inhibitor (secukinumab), and an IL-12/23 inhibitor (ustekinumab).12 Data were collected from population-based health data from the Swedish National Patient Register, Swedish Prescribed Drug Register, and Swedish Cause of Death Registry. Ann Rheum Dis. Janssen Pharmaceutica N.V., Belgium. Treatment with both doses of guselkumab maintained improvements in joint and skin symptoms, dactylitis, enthesitis, and quality of life components through 52 weeks in patients with active PsA who were biologic-naïve or had previous TNFi experience. Both guselkumab doses resulted in significant differences in mean least squares changes from baseline to Week 24 in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores (-2.67 [q8w] and -2.68 [q4w] versus -1.35 [placebo]; p<0.001) and spinal pain (-2.73 [q8w] and -2.48 [q4w] versus -1.30 [placebo]; p<0.001). Efficacy of guselkumab, a monoclonal antibody that specifically binds to the p19-subunit of IL-23, on endpoints related to axial involvement in patients with active PsA with imaging-confirmed sacroiliitis: Week-24 results from two Phase 3, randomized, double-blind, placebo-controlled studies. Read the latest: - EULAR provisional recommendations for the management of rheumatic and musculoskeletal diseases in the context of SARS-CoV-2 - EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2019 update. In the PsABIO cohort comparing ustekinumab with TNFi treatment effectiveness at 12-month follow-up, the observed data showed differences in the proportion of patients achieving MDA, VLDA, cDAPSA low disease activity, and remission in favour of TNFi. ACR20 response rates at Week 52 were 70.6% (q4w) and 74.6% (q8w), with similar response patterns for the ACR50 and 70 criteria. SAT0398 Persistence of ustekinumab (UST) or TNF inhibitor (TNFi) treatment in psoriatic arthritis (PsA): insights from the large, prospective, multinational, real-world PsABIO cohort. Other scientific "e-presentations" and "e-posters" are to include prerecorded videos with slides or PDF posters, as appropriate. Personal program login ×. 5, 2020) – Forbius, a clinical-stage protein engineering company that develops biotherapeutics to treat fibrosis and cancer, today presented the first AVID200 Phase 1b results from its scleroderma development program in a poster tour at the Annual European Congress of Rheumatology (EULAR) 2020. For Psoriasis Area Severity Index (PASI) 90 responses, both guselkumab doses ranked first and second out of 15 interventions and were highly likely to provide a greater benefit for patients, compared with most other agents. 2018;77(Suppl 2):1589-90. EULAR has traditionally been a pre-eminent provider and facilitator of high-quality educational offerings for physicians, health professionals in rheumatology, and people with rheumatic and musculoskeletal diseases. The results show that ustekinumab treatment results in an improved treatment persistency profile, compared with adalimumab.12. ARD supplement - EULAR 2020 Abstract book. 7. The results showed that 121 out of 438 (28%) and 134 out of 455 (29%) patients who began ustekinumab and TNFi treatment, respectively, stopped or switched treatment prior to Month 15, with the probability of treatment persistence decreasing with each subsequent treatment line.11, No statistically significant differences between ustekinumab and TNFi persistence were seen in the PS-adjusted Cox analysis for stopping or switching treatment (ustekinumab versus TNFi) (hazard ratio [HR]: 0.82; 95% confidence interval [CI]: 0.60–1.13). Disclosure: Dr Ritchlin has received grant or research support from AbbVie, Amgen, and UCB; and is a consultant for AbbVie, Amgen, Gilead, Janssen, Eli Lilly and Company, Novartis, Pfizer, and UCB. The selection reflects personal views of the contributors, thus inevitably incomplete; nevertheless, it provides an overview of hot topics that were discussed in each field. European Medical Journal is for informational purposes and should not be considered medical advice, diagnosis or treatment recommendations. EULAR Recommendations 2020. Ann Rheum Dis. Please consult the detailed EULAR Embargo Rules available at 2020. Gossec L et al. EULAR Myositis Study Group - MyoNet. In recent years, several effective biologic treatments for PsA, including TNF inhibitors, IL-12/23 inhibitors, and IL-17 inhibitors, have been introduced. Abstract book pdf . Ritchlin C et al. A study evaluating the efficacy and safety of guselkumab administered subcutaneously in participants with active psoriatic arthritis. EULAR E-CONGRESS, 3-6 June, 2020. The term of your search has to be longer than 3 characters. EULAR: Abstracts submitted to the annual EULAR Congress. Ann Rheum Dis. A significantly greater proportion of guselkumab-treated patients also achieved BASDAI 50 responses (40.5% [q8w] and 37.9% [q4w]), compared with placebo (19.1%; p<0.01 for both doses) at Week 24.6, A network meta-analysis of 26 Phase III studies comparing guselkumab treatment with other targeted therapies for PsA showed that guselkumab treatment is comparable to most treatments regarding improvements in arthritis, soft-tissue damage, physical function, and safety outcomes. Abstracts for EULAR 2020 are available via the Abstract Archive. NCT03158285. Read full article. Austin, TX, and Montreal, QC (Jun. Similar response patterns were also seen for the more rigorous ACR50 and 70 criteria.2 Response rates were comparable in patients who had received prior TNFi treatment, and in patients who crossed over to guselkumab treatment at Week 24. Treatment was safe and well tolerated, and consistent with previous studies regarding guselkumab safety in psoriasis.5, In the DISCOVER-2 trial, outcome measurements included ACR response rates and a PsA-modified van der Heijde–Sharp (vdH-S) score measuring joint damage progression. SAT0397 Guselkumab, an IL-23 inhibitor that specifically binds to the IL-23p19-subunit, for active psoriatic arthritis: one year results of a Phase 3, randomized, double-blind, placebo-controlled study of patients who were biologic-naïve or TNFα inhibitor-experienced. Email: posters@wolterskluwer.com Phone Number: Monday through Friday,8:00 AM - 4:30 PM Central Daylight Time Customers within the US: (800) 450-4194 (toll free) or (507) 323-8500. This year’s congress was a truly remarkable celebration of scientific and educational excellence in a new online format, keeping faith with EULAR’s commitment to be the prime platform for rheumatology information exchange and professional education in … Create your own personal healthcare feed, full of the latest content from across our divisions. It was founded in 2017 as a fully integrated operational entity. University of Leeds, Leeds, UK 4. Alpine Immune Sciences, Inc. (NASDAQ: ALPN), a leading clinical-stage immunotherapy company focused on developing innovative treatments for cancer and autoimmune/inflammatory diseases, today announced that the company will present two posters at the EULAR 2020 E-Congress, taking place virtually June 3-6, 2020. OP0056 Persistence of biologic treatment in psoriatic arthritis: a population-based study in Sweden. Deadlines apply at 23:59 CET . Please remember to register in order to attend the e-congress event. Prof Smolen has received grant or research support from AbbVie, AstraZeneca, Celgene, Celltrion, Chugai, Eli Lilly and Company, Gilead, ILTOO Pharma, Janssen, Novartis-Sandoz, Pfizer, Samsung, and Sanofi; and is a consultant for AbbVie, AstraZeneca, Celgene, Celltrion, Chugai, Eli Lilly and Company, Gilead, ILTOO Pharma, Janssen, Novartis-Sandoz, Pfizer, Samsung, and Sanofi. Please note that session titles vary from one year to the next. Cookie Policy. SOUTH SAN FRANCISCO, Calif., June 3, 2020 /PRNewswire/ -- Rigel Pharmaceuticals, Inc.. (Nasdaq: RIGL) today announced that data related to R835, the company's investigational IRAK1/4 inhibitor, will be presented in two oral and two poster presentations at the European League Against Rheumatism (EULAR) 2020 E-Congress taking place June 3-6, 2020.A fifth abstract highlighting … Sorbonne Université, Paris, France 94 were here. SOUTH SAN FRANCISCO, Calif., June 3, 2020 /PRNewswire/ -- Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) today announced that data related to R835, the company's investigational IRAK1/4 inhibitor, will be presented in two oral and two poster presentations at the European League Against Rheumatism (EULAR) 2020 E-Congress taking place June 3-6, 2020. Medical University of Vienna, Vienna, Austria The results of the Phase III DISCOVER-1 and -2 trials with guselkumab and the PsABIO trials with ustekinumab show that these treatments result in sustained improvements in skin, joint, and soft-tissue manifestations of PsA, with no new safety signals, in adult patients with active PsA. For this reason, we are delighted to … June 2020, 10:20 AM - … University of Glasgow, Glasgow, UK https://clinicaltrials.gov/ct2/show/NCT02627768. 6. E-Mail Password Details of the presentations are as follows: GUIDELINES FOR EULAR POSTERS ... All accepted abstracts submitted for the 2020 EULAR E-Congress are subject to an embargo until Wednesday, 03 June 2020, 00:01 CET. Ts & Cs Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License. Prof McInnes has received grant or research support from Bristol-Myers Squibb, Celgene, Eli Lilly and Company, Janssen, and UCB; and is a consultant for AbbVie, Bristol-Myers Squibb, Celgene, Eli Lilly and Company, Gilead, Janssen, Novartis, Pfizer, and UCB. EULAR Congress 2020. In the multivariate sensitivity analysis, both ustekinumab (HR: 0.81; 95% CI: 0.70–0.94) and secukinumab (HR: 0.82; 95% CI: 0.70–0.95) treatment resulted in significantly lower discontinuation rates, compared with adalimumab. Creative Commons Attribution-Non Commercial 4.0 License. All congress materials are still available on the 2020 EULAR Congress Portal until September 2020, Ann Rheum Dis. We remain committed however to meeting our scientific, educational and training obligations. Comparisons of 6- and 12-month unadjusted data showed sustained MDA and VLDA responses with both ustekinumab (21.8%) and TNFi (29.5%) treatment, with similar proportions of patients achieving these targets between Months 6 and 12 (17.0% and 20.3%, respectively).10, A comparative analysis of 1-year persistence of ustekinumab and TNFi within the PsABIO cohort showed a promising persistence profile for ustekinumab. Customer Service. University of Rochester Medical Center, Rochester, New York, USA Bursary grants. All the abstracts submitted to a EULAR Congress are compiled and published in an Abstract Book. Mr Geale is a consultant for Quantify Research and has indirectly participated as a consultant for several speakers bureaus. EULAR 2020 - PROGRAMME BACK TO SCHEDULE BACK. NCT02627768. A study evaluating the efficacy and safety of guselkumab administered subcutaneously in participants with active psoriatic arthritis including those previously treated with biologic anti-tumor necrosis factor (TNF) alpha agent(s) (Discover-1). Support: The posters, presentations, and publication of this article were funded by Janssen. AB0820 Comparative efficacy of guselkumab in patients with psoriatic arthritis: results from systematic literature review and network meta-analysis. Janssen Research & Development, LLC. About EULAR 2021 Congress. Welcome to the EULAR 2020 Report. Ç; š;ˆæŸG‡t±ê‚PÆlNڽູÞ'AóÑB¦u. Abstract OP0054. The European League Against Rheumatism (EULAR) is … Rigel to Present Four Posters Highlighting IRAK1/4 Inhibitor at the EULAR 2020 E-Congress News provided by. Meissner Y, Fischer-Betz R, Andreoli L, et al EULAR recommendations for a core data set for pregnancy registries in rheumatology Annals of the Rheumatic Diseases Published Online First: 14 October 2020. doi: 10.1136/annrheumdis-2020-218356 Read recommendation oral reports and posters from the various areas of rheumatology. However, after propensity score (PS) adjustment for baseline differences, there were no significant differences in odds ratios between the groups for achieving these targets at 12 months. Changes in vdH-S scores in Weeks 0–24 (0.62) and Weeks 24–52 (0.46) were comparable in patients receiving the q4w dose; less radiographic progression occurred in Weeks 24–52, compared with Weeks 0–24, for patients receiving the q8w dose (0.23 versus 0.73) and for patients receiving the q4w dose compared with placebo (1.00 versus 0.25). Ann Rheum Dis. Psoriatic arthritis (PsA) is a chronic, heterogeneous, immune-mediated arthritis characterised by joint inflammation and diverse clinical manifestations including psoriasis, peripheral and/or axial joint disease, enthesitis, and dactylitis. 2020;79(1):1149-50. MD Féline Kroon, Netherlands. The European Congress on Rheumatology (EULAR) has accepted an abstract co-authored by STATinMED Research, for poster presentation at EULAR 2019, to … A total of 3,620 discontinuation events across 4,649 treatment exposures (adalimumab: 3,255; secukinumab: 887; ustekinumab: 507) were found in the main analysis. 2020;79(Suppl 1):1713-4. McInnes I et al. The abstracts published herein are covered by copyright and exclusive licence to EULAR/BMJ Publishing Group. 2020;7[1]:44-48. Presenters: Christopher T. Ritchlin,1 Iain B. McInnes,2 Philip Helliwell,3 Josef F. Smolen,4 Laure Gossec,5 Kirk Geale6,7, 1. Highlights of prescribing information Tremfya®. Both guselkumab doses ranked in the top five out of 19 interventions regarding adverse events and severe adverse events, comparable to IL-17A inhibitors and TNFi agents.7, The PsABIO study evaluated the effectiveness, tolerability, and persistence of first-, second-, or third-line treatment with ustekinumab or TNFi in PsA, and included outcome data for patients achieving minimal disease activity (MDA) or very low disease activity (VLDA), as well as clinical Disease Activity in PSoriatic Arthritis (cDAPSA) low disease activity and remission.8-10 The 12-month follow-up study included 929 eligible patients, of whom 438 received ustekinumab and 455 received a TNFi.10, The introduction of IL-12/23 inhibition with ustekinumab heralded the first new biologic mode of action after TNFi, though there is a current lack of real-world data comparing these therapies in patients with PsA. 2020;79(1):1152-3. Each year, more than 4,000 abstracts are submitted for review and are published in the Abstract Book or personally presented at the scientific or poster sessions at the congress. 2020 E-Congress Abstracts from 2005 onwards contain the citation reference. For the ACR20 response, the q4w and q8w guselkumab doses ranked fifth and eighth, respectively, out of 20 interventions, and were comparable to IL-17A inhibitors and most TNFi agents, with similar findings for ACR50 and 70 responses. Helliwell P et al. Prof Gossec has received grant or research support from Eli Lilly and Company, Mylan, Pfizer, and Sandoz; and is a consultant for AbbVie, Amgen, Biogen, Celgene, Janssen, Eli Lilly and Company, Novartis, Pfizer, Sandoz, Sanofi-Aventis, and UCB. Several ongoing studies are examining the potential efficacy and safety of PsA treatments, including the monoclonal antibodies guselkumab, which specifically binds to the p19-subunit of IL-23, and ustekinumab, which binds to IL-12/23. Alpine Immune Sciences Announces Poster Presentations at EULAR 2020. 2019. Smolen JS et al. Biennial report 2020 Congress poster 2019. This study group is an open forum designed to enhance knowledge on myositis and to facilitate research and clinical trials in myositis. Placebo patients crossed over to guselkumab q4w at Week 24.2 The DISCOVER-2 trial design was similar to that of DISCOVER-1,3 and examined treatment efficacy and safety through Week 52, but in 739 patients with active PsA who were biologic-naïve.4, In the DISCOVER-1 trial, patients receiving guselkumab 100 mg q4w and q8w showed improved American College of Rheumatology (ACR) 20% improvement criteria (ACR20) response rates, which were maintained at Week 52 in 73.4% (q4w) and 59.8% (q8w) of patients. Acknowledgements: Medical writing assistance was provided by Megan Breuer, Excerpta Medica, Amsterdam, the Netherlands. Ann Rheum Dis. Customers outside the US: +31 229 211980 The views and opinions expressed are those of the presenters and not necessarily of Janssen. Persistence was compared using a Cox regression analysis, with PS adjustments for baseline imbalances in and...: a population-based study in Sweden š ; ˆæŸG‡t±ê‚PÆlNڽູÞ'AóÑB¦u assume you 're with... Treatments for psoriatic arthritis from EULAR 2020 8 European countries ( PsABIO ) Against! Please refer to the annual EULAR congress Portal until September 2020, Customer Service Against Rheumatism ( ). Op0056 Persistence of ustekinumab in Sweden alpha Inhibitor therapies in participants with active arthritis. Journal is for informational purposes and should not be considered Medical advice, diagnosis or treatment Recommendations ). Has been cancelled due to the following guidelines and upload your presentation latest by 31 May 2020 PASI 90 to. 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That your Abstract submission and/or the acceptance of abstracts does not provide registration to annual. Please note that your Abstract submission and/or the acceptance of abstracts does not provide registration to the event. Posters Highlighting IRAK1/4 Inhibitor at the European League Against Rheumatism ( EULAR ) E-Congress... Attribution-Non Commercial 4.0 License treatment results in an Abstract Book under the terms of Creative. Of Janssen across our divisions latest content from across our divisions, full of the Creative Commons Commercial... Christopher T. Ritchlin,1 Iain B. McInnes,2 Philip Helliwell,3 Josef F. Smolen,4 Laure Kirk... For Quantify research and clinical trials in myositis and the evolution of gastrointestinal tract GIT... [ äã¬gי¬J } ¢ìÎîoÖ+´îî㹌Ҽž¢›P Ç ; š ; ˆæŸG‡t±ê‚PÆlNڽູÞ'AóÑB¦u support: the posters presentations!